Gmnn Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comGmnn Polyclonal Antibody for Mouse(Mus musculus)

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Index > Protein center > Gmnn(Gene name) > Mouse

Gmnn (Gene name),

Geminin (Protein name ), GEMI_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gmnn;

Protein name:

Geminin;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer (By similarity). Interacts with IDAS; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization (By similarity). Interacts with CDT1; inhibits binding of the MCM complex to origins of replication.

Function:

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.

Subcellular Location:

Cytoplasm Nucleus Mainly cytoplasmic but can be relocalized to the nucleus.

Protein Attributes:

Sequence length:

206

Sequence:

50:

100:

150:

200:

206:

DARPCT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000006898

SMR:

O88513

Pfam:

PF07412

KEGG:

mmu:57441

String:

O88513

UniGene:

Mm.12239

Uniprot:

O88513

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ELISA Kit for Mouse Geminin

Cat.:

E15220m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Geminin

Cat.:

E15220h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Geminin

Cat.:

U15220m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Geminin

Cat.:

U15220h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Geminin

Cat.:

P15220Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Geminin

Cat.:

P15220Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Geminin

Protein for Mouse Geminin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Geminin, an inhibitor of DNA replication, is degraded during mitosis."
McGarry T.J. , Kirschner M.W.
Cell93:1043-1053(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DEVELOPMENTAL STAGE
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity."
Yanagi K. , Mizuno T. , You Z. , Hanaoka F.
J. Biol. Chem.277:40871-40880(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CDT1
4.

"Structural basis for inhibition of the replication licensing factor Cdt1 by geminin."
Lee C. , Hong B. , Choi J.M. , Kim Y. , Watanabe S. , Ishimi Y. , Enomoto T. , Tada S. , Kim Y. , Cho Y.
Nature430:913-917(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 79-157 IN COMPLEX WITH CDT1;DOMAIN COILED COIL;SUBUNIT

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